Determinants Of Antimalarial Resistance

Many factors may potentially contribute to the establishment and spread of drug-resistant malaria.[10] At the molecular level, drug resistance may arise because of several different mechanisms, including changes in drug accumulation within the parasite, alterations in drug efflux mechanisms, and secondary point mutations within parasite enzymes and other drug targets. Single-point mutations within drug targets often render parasites more ''fit'' under drug pressure. These mutational events are accelerated in the presence of subtherapeutic drug dosing, particularly in the case of drugs with long half-lives.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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