Whereas cytogenetics identifies the presence of the t(9;22) translocation as well as other chromosomal abnormalities, documentation of the t(9;22) is successful in only ~95% of cases of CML. In one-half of the remaining patients with a normal karyotype, the BCR-ABL fusion is only detectable at the molecular level, due to a submicroscopic genetic fusion. In those patients with a normal karyotype, who have the clinical and hematological profile of CML, molecular testing serves a primary role in identifying such patients. In the remaining patients negative for both the Philadelphia chromosome and the BCR-ABL fusion, alternative diagnoses must be considered.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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