An important entity in the differential diagnosis of CML is a leukemoid reaction that is nonneoplastic in origin, arising secondary to other causes, including infection. Other myeloproliferative/myelodysplastic disorders, such as atypical chronic myelogenous leukemia and chronic myelomonocytic leukemia, must also be distinguished from CML given their similar clinical presentations; however, both lack the BCR-ABL translocation.
disease. Mechanisms of resistance include 1) amplification of the BCR-ABL chimeric gene at the genomic or transcript level, and 2) point mutations in the kinase domain of BCR-ABL (altering its responsiveness to imatinib).
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.