Eicosanoid Metabolism

Membrane associated proteins in eicosanoid and gluta-thione enzymes including leukotriene C4 synthase, MGST-I, and MGST-II catalyze conversion of LTA4 to LTC4 (Fig. 1). Further, 5-lipoxygenase-associated protein (FLAP) with 5-lipoxygenase facilitates conversion of arachidonic acid via 5-HPETE to LTA4.[1,3] Some cytosolic GST also demonstrate low levels of leukotri-ene C4 synthase activity. MGST-II and MGST-III convert 5-HPETE to 5-HETE. Thus the proportions of FLAP to MGST-II/III determine whether 5-HPETE is converted to LTA4 or 5-HETE. Alpha GST catalyzes the reduction of prostaglandin PGH2 to PGF2a, whereas alpha, sigma, and MGST-I-like-I enzymes catalyze the isomerization of PGH2 to PGD2 and PGE2.[1,3] Alpha, mu, and pi GST also catalyze the inactivation of PGA2 to PGJ2. Glutathione S-transferase enzymes may also indirectly affect eicosanoid synthesis via effects on the levels of lipid hydroperoxide.

Arachidonic acid


Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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