Epidemiology And Clinical Features

415 N-terminal amino acids but shows variability thereafter. The polypeptide is cleaved proteolytically to 20-40-kDa structural proteins, and, for example, the 26-kDa structural protein expresses a neutralization epitope.

Currently, eight serotypes of human astrovirus are recognized (HuAst 1-8) based upon epitopes on ORF2. It is also possible to genotype HuAst by examination of sequence data of ORF1a, ORF1b, and the 5' end of ORF2,[12] and genotypes equivalent to the eight serotypes have been defined. Recently, evidence for a novel recombinant HuAst has been uncovered.[13] There is no cross-reactivity between the HuAst serotypes, and immunity to one does not give immunity to the others. Astroviruses have been detected in diarrheic animals and as a cause of hepatitis in ducks. Phylogenetic analyses of a large collection of sequences from a variety of astroviruses showed that all the HuAst clustered together separate from the nonhuman strains; however, the branching order of the astroviruses was the opposite of their host species indicating the possibility of cross-

species transmission. ]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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