Extracellular Products

Group A streptococci release more than 25 extracellular proteins (not all of which have been well characterized) in culture media and in the infected host as reflected by immunoelectrophoretic analysis of concentrated culture supernates against concentrated human g-globulins[12] and by assay of specific antibodies against streptococcal proteins in human sera.[4,8,10,16] The secreted proteins comprise the membrane-damaging (cytolytic) toxins streptolysin O and streptolysin S, NAD-glycohydrolase, cysteine proteinase, DNAses, other hydrolytic enzymes, and 11 exotoxins of the family of the bacterial superantigens (SAgs). The molecular and immunological aspects of these SAgs and their implications in the pathogenesis of severe streptococcal diseases, particularly toxic shock syndrome (STSS), are thereafter described.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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