Factor X Function

Factor X, the zymogen of the serine protease factor Xa, occupies a pivotal position in coagulation by virtue of the fact that it can be activated through either the contact-activated (intrinsic) pathway or the tissue-factor (extrinsic) pathway. Factor Xa associates with its cofactor, factor Va, on a membrane surface in the presence of Ca2+, to form the prothrombinase complex which activates pro-thrombin to thrombin[1,2] (Fig. 1). Factor X was identified in 1950 by two groups of researchers, independently, and the name of the two patients affected led to its original designation as ''Stuart-Prower'' factor.[3,4] The characteristics of FX deficiency are a prolonged PT and PTT, a serum abnormality in the thromboplastin generation, and a prolonged Russell's viper venom time.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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