Fetal Cells Diagnosis Or Screening

The scarcity of fetal cells in the maternal circulation and the failure to reliably retrieve these cells from maternal blood samples are amply underscored by the sobering results of the NIFTY Study. As even more disappointing results were obtained in the study initiated by Applied Imaging, which used state-of-the-art technology for the automated detection of putative fetal erythroblasts,[5] questions have been raised as to whether the pursuit of fetal cells can have any future diagnostic value.[1] Although it is clear that current technologies are not suited to clinical applications, there are other facets worthy of future exploration. Among these is the observation that the trafficking of fetal cells into the maternal periphery appears to be greater in pregnancies with aneuploid fetuses, particularly in cases with trisomy 21.[6] Furthermore, reports indicating that trophoblast cells may be more prevalent in the maternal circulation than previously thought[7] suggest that unnecessary constraints may have been made in restricting previous studies solely to fetal erythroblasts. Therefore it is possible that a greater degree of success may be attained by casting the net out to catch a wider variety of fetal cells. Furthermore, a sensible strategy may be to move away from a diagnostic setting to a screening one. In such a scenario, the focus would be shifted to the detection of fetal cells only in those instances where suspicion of a fetal aneuploidy exists. These results are used in combination with those obtained from ultrasound and/or serum analyte examination to reduce the relatively high false-positive rate of other methods, or, at best, to obviate the need for any further confirmatory invasive procedures.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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