To date, over 600 mutations have been identified in the FBN1 gene in MFS patients and related diseases (http://www.umd.be). FBN1 gene mutations have been identified in complete and incomplete forms of MFS, but also in various overlapping disorders: severe neonatal MFS, dominantly inherited ectopia lentis, isolated skeletal features of MFS, Shprintzen-Goldberg syndrome, WeilMarchesani syndrome, and familial or isolated forms of aortic aneurysms. These results define the new molecular group of ''type 1 fibrillinopathies.''
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.