Fig. 1 After binding of thrombin to the platelet surface, FVIII and FXI are cleaved. When FIXa binds to the platelet surface, it forms the "Xase" complex together with FVIIIa. The "Xase" complex catalyzes the activation of FX. FXa/Va complexes can now produce the burst of thrombin necessary to form a hemostatic clot. (From Hoffmann et al. Thromb. Haemost. 2001, 85, 958.) (View this art in color at

of zymogenic FX contains three structural domains, each of which possesses distinct functional properties. The heavy chain contains the serine protease domain of 254 amino acids which forms the catalytic triad of the active site.[1'2]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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