Fluoroquinolone Resistance Associated Gene Mutations

Fluoroquinolone resistance ensues from spontaneous point mutations in the quinolone-resistance determining regions (QRDRs) of DNA gyrase and topoisomerase IV. In S. pneumoniae, resistance mutations occur most

Table 1 Fluoroquinolone MIC increase associated with amino acid substitutions in the QRDRs of ParC and GyrA of S. pneumoniae

Amino acid alterations

Fold MIC increase from wild type

Table 1 Fluoroquinolone MIC increase associated with amino acid substitutions in the QRDRs of ParC and GyrA of S. pneumoniae

Amino acid alterations

Fold MIC increase from wild type

GyrA position

ParC position

Ciprofloxacin

Gatifloxacin

Gemifloxacin

Levofloxacin

Moxifloxacin

Ser79Phe

Was this article helpful?

0 0
Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook


Post a comment