Future Developments

Developments and improvements of the array-CGH technique are taking place in order to have a robust technique that can be used in a regular basis in clinical applications. Algorithms that help to accurately define the breakpoints of chromosomal aberrations[40] as well as a fully automated quantification of the image data obtained in microarray experiments1-41-1 have already been developed. Also, array-CGH using spotted oligonucleotides instead of BACs/PACs or cDNAs is currently being approached.[42] These oligos, which are currently used in expression profiling,[43] have the advantage of shortcut-ting the array production as there is no need for culturing and amplifying. Oligo-CGH has high accuracy in detecting amplifications, as with BAC-arrays (Fig. 3). It is also able to detect single-copy alterations, although with less accuracy, which requires further optimization.1-42-1

Finally, as the ultimate goal is to arrive to the gene that is affected by the chromosomal aberration, it is important to merge the array-CGH data with the expression data. Together, these two pieces of information will give a more complete picture of which genes and pathways are involved in the development of the disease.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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