GC content

The GC content of the fragment in question and the sequence flanking the change can influence the ability of HA to detect the mismatch. This is thought to be due to the three-dimensional conformation adopted by the double-stranded DNA which in turn is dependent on the GC content. The relationship of the GC-rich sequence in the region surrounding the mismatch will also influence detection rates especially if the mismatch is buried in the heteroduplex structure compared with a more superficial location.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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