Gene Diagnosis

Becker muscular dystrophy is caused by mutations of the dystrophin gene that is also mutated in DMD.[2] Therefore, both DMD and BMD are sometimes called as dystrophinopathy. Furthermore, not only types but also locations of mutations identified in both BMD and DMD are quite similar.[3] For gene diagnosis of BMD both multiplex PCR and Southern blot analysis have been employed as in the genetic diagnosis of DMD.[4-6] Nearly two-thirds of mutations identified on the dystrophin gene are deletions or duplications occupying a single or multiple exons. Every mutation identified in BMD cases would be examined based on the following reading frame rule.[3] In the rest of the BMD cases it is rather difficult to identify the responsible mutations on the dystrophin gene as a single nucleotide change is supposed to be present. However, some point mutations that induced exon skipping have been reported.[7,8]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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