The complexity of the wide phenotypical heterogeneity in the context of a complex genotype necessitates a multidisciplinary and multistep approach. Good clinical practice presumes interactive work between cardiologists, geneticists, and psychological support. Genetic counseling is used for a general disease information and specifically for prenatal counseling and/or diagnostics if one parent is affected and predictive diagnosis in phenotypical healthy family members. Genetic testing of first-degree family members and relatives should be encouraged. If mutation analysis is not possible, repetitive clinical examination for HCM diagnosis is recommended.
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