Genetic Counseling

When studying a monogenic disease such as Brugada syndrome, it must be understood that the presence of the mutation does not always mean the person will develop the disease (varying penetrance). Brugada syndrome is inherited as an autosomal disorder which means the disease will be present in each generation and 50% of the offspring are expected to inherit the mutant gene and thus be at risk of developing the disease. Like most autosomal dominant disorders, penetrance is age dependent tending to increase with age. Several factors remain unknown as to why onset of the disease is so age dependent. Genes continuously interact with the environment and determine the phenotype, its variability, and its age of onset. The family should undergo ECG screening and genetic testing if possible. However, it is embedded in the general population that genetics determines everything, and they expect the worse from a positive diagnosis. Genetic counseling becomes, in this issue, the most important tool to put this family back to a normal lifestyle.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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