Genetic Diagnosis And Counseling

Long QT syndrome genotyping is progressively entering in the clinical practice. The availability of the genetic diagnosis may allow a more thoughtful clinical management and risk stratification. Genetic counseling should be regarded as a fundamental component of the clinical management, and the availability of effective therapeutic options is the main reason to encourage an early identification of all gene carriers in a family.

Unfortunately, gaps of knowledge and availability still exist and limit a wide spread applicability of genetic testing.

The ''knowledge'' issue is represented by the fact that the molecular screening of the entire open reading frame of the known genes allows identifying a pathogenetic mutation in 60-65% of probands. This implies that there is one or more LQTS gene(s) still to be identified, but it also leads to the practical consequence that a negative result from a molecular genetic lab has no capability of excluding the diagnosis.

On the other hand, the limited availability of laboratories offering clinical genetic testing for LQTS and the lack of fast and low-cost screening methodologies constitute additional limitations.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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