Genetics

Primary-care physicians are playing an increasing role in selecting and counseling patients, and in interpreting genetic test results, which are usually performed in specialized genetic laboratories. Currently, the number of laboratory tests to diagnose monogenic diseases is slowly increasing, and DNA testing is now available for more than 1000 inherited diseases (694 clinical testing and 345 research-only testing) (http://www.geneclinics.org). Mass screening has already commenced for a few of these diseases such as cystic fibrosis, sickle cell disease, hereditary hemochromatosis, and thrombophilias, which have a high prevalence and penetrance. The real challenge lies in the molecular diagnosis and prognosis of complex, multifactorial diseases, but testing for most of these disorders is still experimental. Because of the highly sensitive nature of genetic testing, professional practice guidelines have been developed, and, in addition to these general guidelines, special laboratory guidelines have been developed. It was proposed that testing for disease-causing mutations will become routine, and in time will be used massively in both hospital and community medi-cine,[22] but currently the implementation of POCT for hereditary diseases is impeded by strict regulations.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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