Class II genes are composed of both a-chains and p-chains in the HLA-D region and are responsible for 644 different alleles. The HLA-DQ molecules, consisting of two polymorphic polypeptide chains, account for 24 of the known class II alleles and are thought to be involved in the pathogenesis of several human diseases.[7] The HLA-DQA1 region of the HLA-D gene, located near the centromere, is responsible for assisting in the distinction of intruder cells from the body's own cells, and is one of many locations where the donor and recipient are required to have identical alleles. The DQA1 locus tends to be an ideal area of basic human identification. Because of the small number of known alleles associated with DQA1, substantially less than other areas, it makes a good model for that of other areas. This type of array serves as a model for typing other important gene regions in the HLA complex and can also be used to generate arrays for the detection of single-base changes in other genes of interest.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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