In Vivo Targets for AAV Vectors

The preferred in vivo targets for AAV vectors are cells that are nondividing or turnover relatively slowly. Early studies using AAV2 vectors demonstrated transgene expression in organs such as lung, muscle, liver, brain, and retina[12-14] with persistence for months to years. The relative hierarchy of transduction efficiencies by individual serotypes is not fully clarified, but several other serotypes show enhanced efficiency in various organs.[1] Additional efforts are underway to modify the AAV capsid sequences to alter or enhance targeting of specific cells.[15]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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