Infectious Disease Applications

The development and ongoing improvement of bDNA technology during the past decade was mainly driven by the increasing demand for quantitation of nucleic acids in clinical virology. Understanding the natural history and pathogenesis of chronic viral infections caused, for instance, by hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) has been greatly supported by accurate determinations of viral load. Consequently, measurements of HBV DNA, HCV RNA, and HIV RNA are extensively used in today's clinical practice to monitor the efficacy of antiviral treatment, predict the outcome of therapeutic strategies,

Amplifier Molecules

Capture Extender

* Components containing iso-C/iso-G

Amplifier Molecules

Target RNA

Capture Extender

Preamplifier

Label Extender

Target RNA

Preamplifier

Label Extender

Fig. 1 Overview on the different hybridization probes and amplifier molecules used in the third-generation VERSANT bDNA assays. Iso-C/iso-G: nonnatural, synthetic nucleotides to minimize nonspecific hybridization events (from Bayer Diagnostics).

assess disease progression, and detect the potential emergence of drug-resistant viral strains.[6]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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