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Fig. 3 Pedigree of a melanoma family, illustrating incomplete penetrance, the occurrence of pancreatic cancer, melanoma in a nonmutation carrier, and the lack of segregation of atypical nevi with carrier status. + = CDKN2A mutation-positive, — = CDKN2A mutation negative, M = melanoma, Pa=pancreatic carcinoma, ? = cancer of unknown origin. Numbers underneath individuals depict numbers of atypical nevi.

suggested the occurrence of melanoma predisposition genes on 1p36 and in the region of the HLA complex on 6p21.[21]

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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

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