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'References are listed in Ref. [2].

bPhenotype frequencies adopted from: http://www.nibsc.ac.uk.

cThe old nucleotide positions are listed. For newly assigned nucleotide positions, see Ref. [3]. Source: Modified after Ref. [2].

'References are listed in Ref. [2].

bPhenotype frequencies adopted from: http://www.nibsc.ac.uk.

cThe old nucleotide positions are listed. For newly assigned nucleotide positions, see Ref. [3]. Source: Modified after Ref. [2].

identified as carriers of platelet alloantigenic determinants. Some of these glycoproteins are part of the integrin family and are membrane glycoprotein heterodimers consisting of noncovalently associated a and p subunits. Two platelet membrane receptors that figure prominently in the antigenic profile of platelets, the cohesion receptor GP Ilb-IIIa, now called aIIbp3, and the collagen receptor GP Ia-IIa (a2p3), are integrins. The GP Ib-IX-V receptor, as another carrier of antigenic epitopes, is an integrin as well. The cohesion receptor is expressed up to 80,000 times on the platelet surface and mediates the common cohesive pathway with adhesive proteins such as the von Willebrand factor and fibrinogen. The platelet collagen receptor plays a major role in the adhesion of platelets to collagens. The Ib-IX-V complex functions as a receptor for von Willebrand factor and enables platelets to interact with blood vessel walls under physiological or stress conditions. Cartoons of GP Ilb-IIIa, GP Ia-IIa, and the receptor complex GP Ib-IX-V with major HPA sites are shown in Fig. 1. Their CD nomenclature, their Genbank accession numbers, and their corresponding HPAs are listed in Table 2.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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