nucleic acid. Curr. Issues Mol. Biol. 1999, 1 (2), 89104.

Boffa, L.C.; Morris, P.L.; Carpeneto, E.M.; Louissaint, M.; Allfrey, V.G. Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence. J. Biol. Chem. 1996, 271, 13228-13233.

Nielsen, P.E.; Egholm, M.; Buchardt, O. Sequence specific transcription arrest by PNA bound to the template strand. Gene 1994, 149, 139-145.

Hanvey, J.C.; Peffer, N.J.; Bisi, J.E.; Thomson, S.A.; Cadilla, R.; Josey, J.A.; Ricca, D.I.; Hassman, C.F.; Bonham, M.A.; Au, K.G.; Carter, S.G.; Bruckenstein, D.A.; Boyd, A.L.; Noble, S.A.; Babiss, L.E. Antisense and antigene properties of peptide nucleic acids. Science 1992, 258, 1481-1485.

Mologni, L.; Lecoutre, P.; Nielsen, P.E.; Gambacorti-Passerini, C. Additive antisense effects of different PNAs on the in vitro translation of the PML/RARalpha gene. Nucleic Acids Res. 1998, 26, 1934-1938. Doyle, D.F.; Braasch, D.A.; Simmons, C.G.; Janowski, B.A.; Corey, D.R. Inhibition of gene expression inside cells by peptide nucleic acids: Effect of mRNA target sequence, mismatched bases, and PNA length. Biochemistry 2001, 40, 53-64.

Pooga, H.; Soomets, U.; Hallbrink, M.; Valkna, A.; Saar, K.; Rezaei, K.; Kahl, U.; Hao, J.X.; Xu, X.J.; Wiesenfeld-Hallin, K.; Hokfelt, T.; Bartfai, T.; Langel, U. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol. 1998, 16, 857-861.

Fraser, G.L.; Holmgren, J.; Clarke, P.B.; Wahlestedt, C. Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids. Mol. Pharmacol. 2000, 57, 725-731.

Nielsen, P.E.; Egholm, M.; Berg, R.H.; Buchardt, O. Peptide nucleic acids (PNAs): Potential antisense and antigene agents. Anti-Cancer Drug Des. 1993, 8, 5363.

Misra, H.S.; Pandey, P.K.; Modak, M.J.; Vinayak, R.; Pandey, V.N. Polyamide nucleic acid-DNA chimera lacking the phosphate backbone are novel primers for polymerase reaction catalyzed by DNA polymerases. Biochemistry 1998, 37, 1917-1925. Orum, H.; Nielsen, P.E.; Egholm, M.; Berg, R.H.; Buchardt, O.; Stanley, C. Single base pair mutation analysis by PNA directed PCR clamping. Nucleic Acids Res. 1993, 21, 5332-5336.

Fiandaca, M.J.; Hyldig-Nielsen, J.J.; Gildae, B.D.; Coull, J.M. Self-reporting PNA/DNA primers for PCR analysis. Genome Res. 2001, 11, 609-613.

Bukanov, N.O.; Demidov, V.V.; Nielsen, P.E.; Frank-Kamenetskii, M.D. PD-loop: A complex of duplex DNA with an oligonucleotide. Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 5516-5520.

Perry-O'Keefe, H.; Yao, X.W.; Coull, J.M.; Fuchs, M.; Egholm, M. Peptide nucleic acid pre-gel hybridization: An alternative to Southern hybridization. Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 14670-14675.

16. Jensen, K.K.; Orum, H.; Nielsen, P.E.; Norden, B. Hybridization kinetics of peptide nucleic acids (PNA) with DNA and RNA studied with BIAcore technique. Biochemistry 1997, 36, 5072-5077.

17. Lansdorp, P.M.; Verwoerd, N.P.; van de Rijke, F.M.; Dragowska, V.; Little, M.T.; Dirks, R.W.; Raap, A.K.; Tanke, H.J. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 1996, 5, 685-691.

18. Mathioudakis, G.; Storb, R.; McSweeney, P.A.; Torok-Storb, B.; Lansdorp, P.M.; Brummendorf, T.H.; Gass, M.J.; Bryant, E.M.; Storek, J.; Flowers, M.E.; Gooley, T.; Nash, R.A. Polyclonal hematopoiesis with variable telo-mere shortening in human long-term allogeneic marrow graft recipients. Blood 2000, 96, 3991-3994.

19. Chen, C.; Wu, B.; Wei, T.; Egholm, M.; Strauss, W.M. Unique chromosome identification and sequence-specific structural analysis with short PNA oligomers. Mamm. Genome 2000, 11, 384-391.

20. Taneja, K.L.; Chavez, E.A.; Coull, J.; Lansdorp, P.M. Multicolor fluorescence in situ hybridization with peptide nucleic acid probes for enumeration of specific chromosomes in human cells. Genes Chromosomes Cancer 2001, 30, 57-63.

21. Chen, C.; Hong, Y.K.; Ontiveros, S.D.; Egholm, M.; Strauss, W.M. Single base discrimination of CENP-B repeats on mouse and human chromosomes with PNA-FISH. Mamm. Genome 1999, 10, 13-18.

22. Pellestor, F.; Andréo, B.; Taneja, K.; Williams, B. PNA on human sperm: A new approach for in situ aneuploidy estimation. Eur. J. Hum. Genet. 2003, 11, 337-341.

23. Serakinci, N.; Koch, J. Detection and sizing of telomeric repeat DNA in situ. A performance comparison of PRINS and PNA assays. Nat. Biotechnol. 1999, 17, 200-201.

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