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ASOM, asialoorosomucoid; EGFR, epidermal growth factor receptor; GM-CSF, granulocyte macrophage-colony stimulating factor; LDL, low density lipoprotein; PEI, polyethylenimine; TfR, transferrin receptor; TNF, tumor necrosis factor.

ASOM, asialoorosomucoid; EGFR, epidermal growth factor receptor; GM-CSF, granulocyte macrophage-colony stimulating factor; LDL, low density lipoprotein; PEI, polyethylenimine; TfR, transferrin receptor; TNF, tumor necrosis factor.

murine tumor models.[21] The gene expression of TNF-alpha was localized within the tumor; no significant systemic TNF-related toxicities were observed. Systemic administration of combined p21(WAF-1) and GM-CSF genes formulated into EGF receptor-targeted polyplexes inhibited the growth of subcutaneous hepatoma cells and increased the survival rate of tumor-bearing mice.[24] It remains to be demonstrated whether encouraging findings such as those obtained in mice can be transferred to studies in larger animals and humans.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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