Interpretation

A negative RT-PCR result renders CML extremely unlikely, but does not definitively exclude the diagnosis given the rare variant breakpoints alluded to above. Similarly, a positive RT-PCR result does not definitively invoke a diagnosis of CML, given that BCR-ABL fusion transcripts have been identified in the blood of as many as two-thirds of healthy individuals using an extremely sensitive nested RT-PCR technique.[13] However, whereas the majority of CML patients express either the e13a2 or the e14a2 chimeric transcripts, healthy individuals express primarily the e1a2 type. Furthermore, the extreme level of sensitivity achieved 10"8) with this nested technique is neither required nor recommended for diagnostic clinical testing, and thus misdiagnosis should not be an issue.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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