Our understanding of the genetic basis of aminoglycoside-induced deafness (AID) has greatly improved during the past 15 years. The discovery of the first mitochondrial mutation (A1555G) in 1993, leading to susceptibility to aminoglycoside ototoxicity, was the most remarkable success in this area. Many individuals from different parts of the world have since been identified with this mutation, suggesting that the number of people at risk for ototoxicity may be considerably high, especially in some populations. Two other mutations in the mitochondrial 12S ribosomal RNA (rRNA) gene, C1494T and 961delTinsC(n), have been implicated to cause AID.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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