Introduction

Our understanding of the genetic basis of aminoglycoside-induced deafness (AID) has greatly improved during the past 15 years. The discovery of the first mitochondrial mutation (A1555G) in 1993, leading to susceptibility to aminoglycoside ototoxicity, was the most remarkable success in this area. Many individuals from different parts of the world have since been identified with this mutation, suggesting that the number of people at risk for ototoxicity may be considerably high, especially in some populations. Two other mutations in the mitochondrial 12S ribosomal RNA (rRNA) gene, C1494T and 961delTinsC(n), have been implicated to cause AID.

Hearing Aids Inside Out

Hearing Aids Inside Out

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