This brief presentation cannot replace in-depth textbooks (e.g., Gelfand et al.). The principle of the polymerase chain reaction (PCR) method is outlined in Fig. 1. Although it looks simple, a genius like Kary Mullis was needed for its invention, initially using the heat-labile Klenow enzyme as DNA polymerase, which had to be replenished in each amplification cycle. Mullis, at that time employed by Cetus Corporation in California, was awarded the Nobel Prize in Chemistry in 1993. Since then, PCR technology has radically changed the face of medicine and biology. The basics of the method and some special applications will be outlined.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.