Familial adenomatous polyposis (FAP) represents the classic paradigm for the hereditary cancer syndromes. It is a highly penetrant autosomal dominant disorder with classic Mendelian inheritance of mutations in the ade-nomatous polyposis coli (APC) gene and characteristic genotype-phenotype correlation. Familiarity with the natural history of the syndrome, inheritance pattern, and the colonic and extracolonic clinical manifestations is essential for early identification of families at risk. A combination of genetic counseling, genetic testing, and aggressive endoscopic surveillance is paramount to management. Surgical management is the cornerstone of therapy as chemopreventive measures continue to be developed.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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