Introduction

Familial adenomatous polyposis (FAP) represents the classic paradigm for the hereditary cancer syndromes. It is a highly penetrant autosomal dominant disorder with classic Mendelian inheritance of mutations in the ade-nomatous polyposis coli (APC) gene and characteristic genotype-phenotype correlation. Familiarity with the natural history of the syndrome, inheritance pattern, and the colonic and extracolonic clinical manifestations is essential for early identification of families at risk. A combination of genetic counseling, genetic testing, and aggressive endoscopic surveillance is paramount to management. Surgical management is the cornerstone of therapy as chemopreventive measures continue to be developed.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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