The long QT syndrome (LQTS) is an inherited arrhyth-mogenic disease occurring in the structurally normal heart that may cause sudden death and that usually manifests in children and teenagers. The estimated prevalence of this disorder is between 1:10,000 and 1:5000. Two major phenotypic variants have been originally described in early 1960s one autosomal dominant, the Romano-Ward syndrome[1] and one autosomal recessive, the Jervell and Lange-Nielsen syndrome. Both variants share a common cardiac phenotype but Jervell and Lange-Nielsen syndrome is also associated with neurosensorial deafness. The Romano-Ward syndrome accounts for the vast majority of LQTS cases.[2] In early 1990s, the discovery of the genetic bases of LQTS provided novel tools for the understanding of the pathophysiology of this disease. The most relevant genetic and phenotypic features will be reviewed in this article.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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