Introduction

The padlock probe or circularizable oligonucleotide probe (C-probe) is a unique molecule that offers significant advantages over conventional oligonucleotide probes. A closed circular structure forms through ligation of its ends after hybridization onto a target, and locks onto its target due to helical turns formed between complementary sequences of the target and the padlock probe. The nature of padlock and stringent requirement for ligation make this probe especially useful for in situ hybridization and detection of single-nucleotide polymorphisms (SNPs).

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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