Introduction

Hepatitis B virus (HBV) infection remains a major health problem in many regions of the world. Antiviral treatment of chronic hepatitis B aims to reduce viral replication and/or to affect the immune response to the virus and virus-infected cells. Development of reverse transcriptase inhibitors such as lamivudine, which has been shown to be a safe and potent inhibitor of HBV replication, has facilitated major advances in the antiviral treatment of chronic hepatitis B.[1,2] Today, lamivudine is a first-line therapy for prophylaxis of HBV recurrence in decompensated cirrhotic patients and liver transplant recipients. In most patients, treatment with lamivudine results in a substantial reduction of the serum HBV DNA level and normalization of serum alanine aminotransferase.1-2,3-1 Moreover, therapy with lamivudine has been shown to improve liver function and histology, to produce hepatitis B e antigen/antibody seroconversion in a substantial proportion of patients, and slow disease progression in patients with cirrhotic liver disease.[2,3] In combination with hepatitis B immunoglobulin, lamivudine has been demonstrated to be effective in preventing recurrence of infection after liver transplantation.[4] Lamivudine is also effective in patients infected with precore mutants of HBV.[5] Relapse following the cessation of lamivudine therapy, however, is common and seroreversion from hepatitis B e antibodies to hepatitis B e antigen may occur.[6]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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