Hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, also known as Lynch syndrome, is due to germline mutation in mismatch repair (MMR) genes. It represents a highly penetrant autosomal dominant disorder with classic Mendelian distribution. Although it lacks a pathognomonic phenotype characteristic often seen in some hereditary cancer syndromes, there are some fundamental clinical characteristics that should raise suspicion to the possibility of this diagnosis. A combination of genetic counseling, genetic testing, and aggressive endoscopic surveillance is paramount to management. Surgery remains the definitive therapy in HNPCC-affected patients, but the appropriate role for prophylactic resection remains to be delineated.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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