Introduction

Analysis of the complex mechanisms that initiate neoplastic changes and drive the progression of precursor lesions to cancer is a cornerstone of cancer research. These mechanisms in general consist of a spiral of (epi)genetic alterations followed by altered gene expression patterns, which cause biological changes at the cell and tissue level. Ultimately, these changes lead to clonal outgrowths of cells that, because of genomic instability, are prone to further genetic alterations. In many types of cancer, most of these genomic alterations occur at the chromosomal level, either as numerical changes or as structural rearrangements, making chromosomal instability one of the key factors in tumor progression.

Analysis of numerical chromosomal aberrations has proven to be very informative, as can be deduced from the multitude of published studies based on heterozygosity (LOH), comparative genomic hybridization (CGH), and fluorescence in situ hybridization (FISH). However, to fully appreciate the role of chromosomal instability in tumor progression, structural aberrations also need to be taken into account.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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