Introduction

The prion protein gene (PRNP) encodes the primary structure of a cellular protein, the prion protein (PrP). If present in a partially protease resistant isoform, caused by either mutations in the PRNP or an infectious process believed to involve template-directed misfolding of the PrP, the same protein can display the puzzling characteristics of a unique, presumably protein-only, infectious agent. Creutzfeldt-Jakob disease (CJD) and kuru are human transmissible spongiform encephalopathy diseases characterized by the deposition of this aberrant form of the PrP. Susceptibility to accumulation of the pathological isoform of the protein, initiated through either spontaneous or inherited PRNP mutation, or exposure to the infectious agent through iatrogenic or alimentary routes, as well as severity and course of disease development are influenced or even determined by the M129V polymorphism of the prion protein gene. For certain applications, it may be possible to exploit this observation for diagnostic purposes to enhance the safety of particular biological medicinal products, such as corneal grafts.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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