Mass spectrometry (MS), in general, is concerned with generating, separating, and detecting gas-phase ions. The underlying concept goes back to 1913 and was demonstrated by Thomson[1] in a series of cathode ray tube experiments. One of the inherent limitations of MS is the need to convert the analyte molecules or atoms into gasphase ions because electromagnetic forces can easily manipulate those and they can readily be detected. This necessity has hampered the widespread use of mass spec-trometric techniques in the biological sciences because it usually results in severe decomposition of biological macromolecules. Matrix-assisted laser desorption/ioniza-tion (MALDI) time-of-flight (TOF) MS, as practiced today, goes back to a concept introduced in 1989 by Karas and Hillenkamp.[2] With the introduction of this technique, limitations resulting from desorption efficiencies for large biomolecules have been overcome. Consequently, the use of MS techniques is exploding and is becoming more and more a routine.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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