Introduction

Mast cells (MCs) are tissue-fixed hematopoietic cells that store numerous vasoactive and immunoregulatory mediators.1-1-1 A complex network of cytokines is involved in the regulation of growth and differentiation of MCs.[1] A most important growth factor for MCs appears to be stem cell factor (SCF). Notably, SCF induces the development of MCs from uncommitted CD34+ progenitors.[2] The effects of SCF on MCs and MC progenitors are mediated through c-kit, a tyrosine kinase receptor for SCF encoded by the c-kit proto-oncogene.

Systemic mastocytosis (SM) is a clonal disease leading to pathological accumulation of MCs in the bone marrow (BM) and other internal organs.[3] In a high proportion of cases, point mutations in the c-kit gene are detectable.[3-5] The most frequent mutation leads to substitution of valine by aspartate at codon 816 (D816V). This mutation is associated with constitutive activation of c-kit and is considered to play a critical role in the pathogenesis of SM.[5,6] However, the clinical picture in SM is variable, ranging from asymptomatic to highly aggressive courses.[3] Therefore, apart from this mutation, several other factors may influence the clinical course in these patients. The current article provides a short overview on c-kit mutation D816V in SM, with special reference to the application of this molecular defect in the diagnostic workup and staging of SM patients.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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