Introduction

The development of molecular hybridization techniques such as fluorescence in situ hybridization (FISH) has had a major impact in clinical research. At present, FISH is used routinely to identify recurring chromosomal abnormalities associated with hematological malignant diseases. The high sensitivity of this technique provides valuable tools not only for diagnosis, but also for follow-up and detection of minimal residual disease. The combination of G-banding, FISH, and molecular analyses has provided a powerful approach for classifying these malignant diseases into clinically and biologically relevant subgroups, allowing selecting the appropriate therapy, and monitoring the efficacy of therapeutic regimens. FISH not only provides an excellent aid for the clinical management of patients with cancer, but also constitutes a valuable tool for the characterization of chromosomal rearrangements and has been the first step to further molecular studies. Improvements of the FISH technique, including the development of multicolor FISH to detect several chromosomal changes in a single assay, and FICTION, a technique that permits to correlate phenotypic and genotypic cell features, show that FISH will continue having a major impact on efforts to characterize the genetic changes that give rise to human tumors.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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