Introduction

Burkholderia pseudomallei is a causative agent of melioidosis, an infectious disease being recognized increasingly as an important cause of morbidity and mortality in many regions of the world. The organism is a free-living environmental saprophyte bacterium that is limited in its distribution to tropical, subtropical, and in endemic areas especially in the tropical regions of Southeast Asia and in the northern parts of Australia. The increase of worldwide travel and spreading of B. pseudomallei to humans and animals results in the potential for melioidosis to be found around the world. The organism is commonly found in water and soil and is usually transmitted to humans through skin abrasion or by respiratory route.[2] Infection by this organism exhibits interesting clinical features including its ability to cause severe disease, resulting in highly fatal septicemia. The incubation period can be days to many years after infection. This disease affects all age groups in both sexes[3] and could be also found in healthy person or in immunodeficient conditions such as diabetes mellitus.[4] Because this disease may be acute or chronic and can be symptomatically confused with other disease and septicemia caused by other gram-negative bacteria,[2] the most reliable and simple diagnosis is bacterial culture using selective medium. The disadvantage of using bacterial culture is that it is time consuming and the result obtained is often too late to be useful. Moreover, the method is limited to identify noncultivated bacteria and to distinguish the closely related species such as Burkholderia cepacia, Burkholderia mallei, and Burkholderia thailan-densis, a nonvirulent species, as well. In this article, the development of diagnosis methods including the advanced knowledge of genomic and proteomic study will be therefore discussed.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment