Introduction

Burkholderia pseudomallei is a causative agent of melioidosis, an infectious disease being recognized increasingly as an important cause of morbidity and mortality in many regions of the world. The organism is a free-living environmental saprophyte bacterium that is limited in its distribution to tropical, subtropical, and in endemic areas especially in the tropical regions of Southeast Asia and in the northern parts of Australia. The increase of worldwide travel and spreading of B. pseudomallei to humans and animals results in the potential for melioidosis to be found around the world. The organism is commonly found in water and soil and is usually transmitted to humans through skin abrasion or by respiratory route.[2] Infection by this organism exhibits interesting clinical features including its ability to cause severe disease, resulting in highly fatal septicemia. The incubation period can be days to many years after infection. This disease affects all age groups in both sexes[3] and could be also found in healthy person or in immunodeficient conditions such as diabetes mellitus.[4] Because this disease may be acute or chronic and can be symptomatically confused with other disease and septicemia caused by other gram-negative bacteria,[2] the most reliable and simple diagnosis is bacterial culture using selective medium. The disadvantage of using bacterial culture is that it is time consuming and the result obtained is often too late to be useful. Moreover, the method is limited to identify noncultivated bacteria and to distinguish the closely related species such as Burkholderia cepacia, Burkholderia mallei, and Burkholderia thailan-densis, a nonvirulent species, as well. In this article, the development of diagnosis methods including the advanced knowledge of genomic and proteomic study will be therefore discussed.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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