Hereditary breast and ovarian cancer syndrome (HBOC) is an inherited autosomal dominant disorder because of germline mutation in BRCA1 and BRCA2 genes. Inheritance of BRCA mutations confers increased lifetime risk for breast, ovarian, and other malignancies. Individuals with suspected HBOC should undergo thorough pedigree analysis, education, and counseling in regards to genetic testing, disclosure and interpretation of the results, and determination of cancer risk. Comprehensive review of surveillance strategies, chemoprevention, surgical prophylaxis with its limitations and potential adverse effects, and the need for lifelong follow-up and screening for other malignancies is essential.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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