Introduction

Factor X (FX) is one of the vitamin K-dependent (VKD) coagulation factors. Factor X occupies a central position in the coagulation cascade and represents the point of convergence between the intrinsic and extrinsic pathways of blood coagulation. Congenital FX deficiency is a rare autosomal recessive disorder which is heterogeneous for both laboratory and clinical expression. Because of the central role of FX in the coagulation cascade, mutations are rare. To date, about 70 missense mutations as well as 12 others including deletions and one nonsense mutation have also been described. The interpretation of the functional effect of missense mutations is facilitated by the availability of crystal structures, sequence alignments, and molecular modeling, and this is effective in identifying structural perturbations in active sites.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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