Introduction

Hereditary diffuse gastric cancer (HDGC) syndrome is an autosomal-dominant inherited cancer susceptibility syndrome with high penetrance for gastric cancer caused by germline truncating mutation in the E-cadherin (CDH1) tumor-suppressor gene. Male carriers have a 67% lifetime risk for gastric cancer; female carriers have a 83% lifetime risk for gastric cancer and a 39% risk for breast cancer. The syndrome is characterized by early, diffuse, multifocal submucosal involvement, rendering endoscopy and random biopsy inaccurate. Once a carrier is identified, prophylactic total gastrectomy is the only effective treatment.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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