Introduction

Diarrheal disease is the fourth commonest cause of death worldwide and most of the deaths are in children in developing countries. Rotavirus is the major cause of diarrheal disease in children and is increasingly recognized as a problem in adults. The virus is unenveloped and has a characteristic double-shelled capsid (80 nm) with a double-stranded RNA genome. The genome comprises 11 linear segments and each segment encodes one or more virus proteins. The polypeptides are highly variable and thus genetic and antigenic changes occur by mutation (antigenic drift), genome rearrangement, genome reassortment (antigenic shift), and cross-species transmission of animal rotaviruses. Infection can be diagnosed by antigen detection (ELISA) or detection of the genome by reverse transcriptase-PCR (RT-PCR) or polyacrylamide gel electrophoresis (PAGE) of RNA extracted from feces.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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