Introduction

Pharmacogenetics studies the influence of heredity on the interindividual differences in pharmacological response. In detail, it can be divided into two subgroups: pharmacodynamics and pharmacokinetics. Pharmacodynamics investigates the mechanism of action of the administered drug and its consequences on the body, namely, for example, the structure of receptors or carrier proteins. In contrast, pharmacokinetics analyzes the effect of the body on a drug reflecting, for example, its absorption, transformation, and excretion. The studied proteins are most often drug-metabolizing enzymes such as oxidative enzymes. A major role in drug metabolism is played by the cytochrome P450 (CYP) enzymes, which can be subdivided into several families, e.g., CYP1A2, 3A4, 2C9, 2C19, and 2D6. These enzymes are responsible for the oxidative metabolism of the majority of all ther-apeutically applied drugs.

In the following, we focus on cytochrome P450 2D6 (CYP2D6) and cytochrome P450 1A2 (CYP1A2).

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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