Introduction

Transplanting a failing organ or specific cell type is a logical means of restoring function for secretory diseases. While inherently appealing, the lack of suitable donor organs or tissues makes the widespread use of cell transplantation impractical. To overcome this limitation, xenogeneic cells can be encased within a selectively permeable polymeric membrane, known as immunoisolation. Immunoisolation owes much of its foundation to investigators focused on diabetes and Parkinson's disease, showing that islets and dopamine-secreting cells are protected from host rejection by encapsulating them within a semipermeable membrane. Single cells or clusters of cells can be enclosed within a selective, semipermeable membrane barrier that admits oxygen and required nutrients and releases bioactive cell secretions, but restricts passage of larger cytotoxic agents from the host immune defense system. Immunoisolation eliminates the need for chronic immunosuppression and allows the implanted cells to be obtained from human or nonhuman sources, thus avoiding the constraints associated with cell sourcing, which limit the clinical application of unencap-sulated cell transplantation.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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