The insect-transmitted protozoan parasite Trypanosoma cruzi is the causative agent of Chagas' disease, a debilitating condition that has a considerable impact on public health in Latin America. Despite the importance of the infection, the mechanisms underlying the severe pathology associated with the disease are still poorly understood. In addition, the drugs in current use have limited efficacy and there is no immediate prospect of a vaccine. However, research on Chagas' disease is now receiving fresh impetus with the completion of the human and T. cruzi genome projects. Together with the application of postgenome technologies, this is providing new insights into the genetic and biochemical nature of the parasite and the mechanisms and consequences of host-parasite interactions. Rapid progress in these areas should facilitate the development of new chemotherapeutic approaches and provide the tools and reagents necessary to address the complex epidemiology of the disease.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.