The polymerase chain reaction (PCR) has revolutionized molecular biology and has become an indispensable tool in molecular diagnostics. The ligase chain reaction (LCR) and the ligase detection reaction (LDR) were developed as alternative nucleic acid amplification methods for analyzing known point mutations associated with genetic diseases. In contrast to target amplification techniques such as PCR, SDA, 3 SR, and NASBA, LCR and LDR are not based on primer extension, but on amplification of ligated probes.[1,2] Excellent reviews on LCR and its diagnostic applications have been published.[3-7]
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.