Gaucher disease, the most common lysosomal storage disorder, is caused by deficient p-glucocerebrosidase activity and results in progressive accumulation of the substrate in macrophages, leading to hepatosplenomegaly, anemia, thrombocytopenia, skeletal lesions, lung disease, and sometimes neurological involvement. Enzyme replacement therapy (ERT) has proven to be safe and effective. Other strategies including bone marrow transplantation, substrate reduction, enzyme chaperones, and gene therapy have been variously attempted.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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