Introduction

Retinoblastoma is childhood cancer of the eye that originates from developing retina and affects one per 20,000 newborns. Familial aggregation of this retinoblastoma has been recognized in the early 19th century and, since then, this tumor has served as a model for familial cancer. For some time it was assumed all cases of retinoblastoma are hereditary and follow an autosomal dominant pattern of inheritance. Later it was recognized that most patients with tumors in one eye only, which account for about 60% of cases, have a nonhereditary form of this disease.[1] Knudson's seminal two-mutation model set the framework to explain the development of both hereditary and nonhereditary retinoblastoma.1-2-1 His theory also guided the discovery of the causative gene, the RB1.[3] This tumor suppressor gene was the first of a now long list of genes that can cause hereditary predisposition to cancer.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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