Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects approximately 1 in 3500 individuals throughout the world. It displays a high rate of new mutation and complete penetrance. Diagnosis is based on clinical criteria, but molecular testing is now available on a clinical basis. Insights into pathophysiology based on understanding the NF1 gene and the cellular pathway in which it participates are beginning to suggest possible avenues of therapy, with several clinical trials currently under way.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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